• Claudin 6兔單克隆抗體

    Claudin 6兔單克隆抗體

    • 價(jià)格￥1800
    • 規格100ul
    • 貨號HKZ150420
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150420Claudin 6兔單克隆抗體100ul支1800
    Claudin?6
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    Catalog# ?BX50297?Clone# ?BP6274
    Predicted?Molecular Wt:
    23kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID: ??P56747
    Background:
    Claudin-6?is a?member of the CLDN family that?is?expressed?in?epithelial?cell?sheets.?Downregulation?of?Claudin-6?has?been
    reported?in?breast?invasive ductal carcinoma associated with?lymphatic?metastasis which?may?point?to?a?function?of?Claudin-6
    as a tumor suppressor. Claudin-6?is?reported to?play?a?role?in?inhibiting?malignancy?of?breast?cancer?cells?by?inducing?apoptosis,?inhibiting?proliferation and?migration.
    Claudin6?is?rarely expressed?in?normal tissue species,?but?is?highly expressed?in tumor?cells,?especially?in?ovarian?cancer.
    Subcellular?location:
    Membrane & Cytoplasm
    Recommended?Method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Synthetic?peptide. This?information?is?proprietary to?Biolynx.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage Conditions:
    -25°C?to?-18°C
    Shipment?Instructions:
    Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?–?18°C. Avoid?freeze?/ thaw?cycles.
    Recommended?Dilution:
    IHC-P:?????1:100-1:200
    Background?References:
    1.?Shin,?K.?et?al.?(2006) Annu?Rev?Cell?Dev?Biol?22,?207-35.
    2. ?Hewitt,?K.J.?et?al.?(2006)?BMC?Cancer?6,?186.
    Immunohistochemistry?(Formalin/PFA-fixed?paraffin-embedded?sections)?analysis of ?human ovarian?cancer?labelling?Claudin?6????with?BP6274.

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