• VEGF兔單克隆抗體

    VEGF兔單克隆抗體

    • 價(jià)格￥1000
    • 規格100ul
    • 貨號HKZ150359
    • 單位支
    • 品牌HaoKebio

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    品牌商品編碼商品名稱(chēng)規格單位單價(jià)
    HaoKebioHKZ150359VEGF兔單克隆抗體100ul支1000
    VEGF
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    Catalog# ?BX50236?Clone# ?BP6213
    Predicted?Molecular Wt:
    24kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID: ??P15692
    Background:
    Vascular?Endothelial Growth?Factor A?(VEGF-A; formerly VEGF)?belongs to the VEGF/PDGF family?of growth factors?that?play?a?critical?role?in?promoting vascular development. VEGF-A?is?primarily?known for?its function?in?promoting angiogenesis, the
    process?by which?new?bloodvessels are sprouted from?pre-existing?bloodvessels. VEGF-A?has eight?isoforms,?derived?from
    differentially spliced?mRNA variants encoded?by the VEGF-A gene. All?isoforms?contain?a?conserved?receptor?binding?domain,?but differ?in their C-terminal domains that?regulate?binding to?components?in?the?extracellular?matrix.?VEGF-A?is?secreted?by???multiple cell types,?including fibroblasts,?macrophages and some tumor?cells.?Binding?of VEGF-A to?its?cognate?receptors
    (VEGFR2 and to a?lesser extent VEGFR1)?on?the?endothelial?cell?surface?activates the?receptor?and?initiates?downstream?signaling,?resulting?in endothelial cell?proliferation, survival,?migration, and?changes to?vascular?permeability,?all?crucial??processes for angiogenesis.
    Subcellular?location:
    Cytoplasm
    Recommended?method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Recombinant?protein fragment of?human VEGF.
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage conditions:
    -25°C?to?-18°C
    Storage instructions:
    Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
    Recommended?Dilutions:
    IHC-P:?????1:100-1:200
    Background?References:
    1.?Chaudhry?IH, O’Donovan?DG, et?al.?(2001)?.?Histopathology?91:409–415.
    2. ?Boer?K, Troost?D, Spliet?WGM, et?al.(2008)?.?Acta?Neuropathol?115:?683–696.
    Immunohistochemistry
    (Formalin/PFA-fixed?paraffin-
    embedded?sections)?analysis of?human?liver?carcinoma tissue
    labelling?VEGF?with?BP6213.
    Heat?mediated?antigen?retrieval?was?performed?using Tris/EDTA??buffer?pH?9.0

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