• Bcl-6兔單克隆抗體

    Bcl-6兔單克隆抗體

    • 價(jià)格¥1000
    • 規格100ul
    • 貨號HKZ150362
    • 單位
    • 品牌HaoKebio

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    HaoKebioHKZ150362Bcl-6兔單克隆抗體100ul1000
    Bcl-6
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    Catalog# ?BX50239?Clone# ?BP6216
    Predicted?Molecular Wt:
    79kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID: ??P41182
    Background:
    Bcl-6?is a transcriptional?regulator gene which codes for?a?706-amino-acid?nuclear?zinc finger?protein.The?mitogen-activated
    protein?kinases,?Erk1 and?Erk2,?but?not?JNK,?phosphorylate?BCL6 at?multiple?sites.?Phosphorylation?of?BCL6?at?Ser333?and
    Ser343?results?in?degradation?of?BCL6?by?the?ubiquitin/proteasome?pathway?in?B?cells.?In?addition,?BCL6?is?acetylated?and?its
    transcriptional?repressor function?is?inhibited?by the transcriptional co-activator?p300. Antibodies to this?protein stain?the
    germinal center cells?in?lymphoid follicles, follicular cells?and?interfollicular?cells?in?Follicular?Lymphoma,?Diffuse?Large?B-Cell
    Lymphomas,?Burkitt’s?Lymphoma, and the?majority of the?Reed-Sternberg cells?in?Nodular?Lymphocyte-Predominant?Hodgkin’s?Disease.
    Subcellular?location:
    Nuclear
    Recommended?method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Recombinant fragment within?Human?Bcl-6.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage conditions:
    -25°C?to?-18°C
    Storage instructions:
    Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
    Recommended?Dilutions:
    IHC-P:?????1:100-1:200
    Background?References:
    1.?Shvarts, A. et?al.?(2002)?Genes?Dev?16,?681-6.
    2. ?Bereshchenko,?O.R. et?al.?(2002)?Nat?Genet?32,?606-13.
    Immunohistochemistry
    (Formalin/PFA-fixed?paraffin-
    embedded?sections)?analysis of?human?diffuse?large?B cell
    lymphoma tissue?labelling?Bcl-6?with?BP6216.?Heat?mediated
    antigen?retrieval?was?performed?using?Tris/EDTA?buffer?pH?9.0

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