杭州浩克生物
PAX-8 重組兔單克隆抗體
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| 品牌 | 商品編碼 | 商品名稱(chēng) | 規格 | 單位 | 單價(jià) |
|---|---|---|---|---|---|
| HaoKebio | HKZ150147 | Granzyme B兔單克隆抗體 | 100ul | 支 | 1000 |
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50024?Clone# ?BP6029
Predicted?Molecular Wt:
28kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P10144
Background:
Granzyme?B?is serine?proteases that?mediate apoptotic signaling?in cytotoxic T?lymphocytes?(CTL)?and?in?natural?killer?(NK)?cells.?Granzyme?B?is synthesized as?inactive?proenzymes, and they arestored?within?cytolytic?granules?and?released?by?effector?cells????during degradation.
Recent studies?have demonstrated that the expression?of granzyme?B?by?immunohistochemistry?in?several?entities?of?extranodal?peripheral T cell?lymphoma?(PTCL) and?NK cell?lymphomas,?including?nasal and?nasal-type?NK/T?cell?lymphomas,?hepatosplenic
and?non-hepatosplenic?PTCL, enteropathy-type?(ETCL) and?non-ETCL?intestinal?PTCL, subcutaneous?panniculitis-like?PTCL?(SPTCL),?cutaneous CD8+ epidermotropic?lymphomas as well as?in?nodal?and?cutaneous?CD30+?anaplastic?large?cell?lymphomas?(ALCL).
The expression of cytotoxic?proteins, such?as granzyme?B?may?be?important?for?the?identification?and?classification?of?extranodal?T- and?NK-cell?lymphomas since?many of these tumors do?not?have?specific?morphology?and?phenotype.
?Subcellular?location:
Cytoplasm
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to Granzyme?B
residues?within?aa100-200 of?Granzyme?B?was?used?as an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1. ?Froelich?CJ, et.al, J?Immunol.?1993?Dec 15;151(12):7161-71.
2. ?Hodge?G, et.al, Clin?Exp?Immunol.?2014?Oct;178(1):79-?85.
Immunohistochemistry
(Formalin/PFA-fixed
paraffin-embedded
sections?analysis of spleen?tissue?labelling granzyme???B?with?BP6029.?Heat
mediated?antigen?retrieval?was?performed?using
Tris/EDTA?buffer?pH?9.0
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