F8, also named as AHF and F8C, belongs to the multicopper oxidase family. F8, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. F8 can be cleaved to 4 chains: F8a heavy chain, 200 kDa isoform, F8a heavy chain, 92 kDa isoform, F8 B chain and F8a light chain. This antibody can recognize the light chain.
Applications
Tested Applications:
IHC,ELISA
Species Specificity:
human
Positive IHC detected in:
human tonsillitis tissue, human lung cancer tissue
Applications
Tested Applications:
IHC, WB, ELISA
Cited Applications:
IF, IHC, WB
Species Specificity:
human, mouse, rat
Cited Species:
human, mouse, rat
Positive WB detected in:
mouse brain tissue, rat brain tissue
Positive IHC detected in:
mouse brain tissue
Note: suggested antigen retrieval with?TE buffer pH 9.0;?(*) Alternatively, antigen retrieval may be performed with?citrate buffer pH 6.0
Recommended dilution:
WB : 1:2000-1:16000
IHC : 1:50-1:500
Product Information
Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment.?Aliquoting is unnecessary for -20oC storage.
Immunogen Information
?
Full name:
myelin basic protein
Calculated molecular weight:
33 kDa
Observed molecular weight:
17-22 kDa
?
?
Gene symbol
MBP
Synonyms
MBP, Myelin A1 protein, Myelin basic protein
Background
MBP belongs to the myelin basic protein family. The classic group of MBP isoforms (isoform 4-isoform 14) are the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. MBP has six isoforms. Catalog#10458-1-AP is capable of recognizing multiple isoforms of MBP.
Protocols
PRODUCT SPECIFIC PROTOCOLS
?
WB proto
Note: suggested antigen retrieval with?TE buffer pH 9.0;?(*) Alternatively, antigen retrieval may be performed with?citrate buffer pH 6.0
Recommended dilution:
IHC : 1:50-1:500
Product Information
Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment.?Aliquoting is unnecessary for -20oC storage.
Immunogen Information
Full name:
CD7 molecule
Calculated molecular weight:
240 aa, 25 kDa
?
Gene symbol
CD7
Synonyms
CD7, CD7 molecule, GP40, LEU 9, T cell antigen CD7, T cell leukemia antigen, T cell surface antigen Leu 9, Tp40, TP41
Background
CD7 is a 40 kD type I transmembrane glycoprotein expressed on thymocytes and mature T cells. It is the most reliable clinical marker of T-cell acute lymphocytic leukemia.
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