Cytokeratin 1兔單克隆抗體

價(jià)格￥600
規格100ul
貨號HKZ150195
單位支
品牌HaoKebio

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品牌	商品編碼	商品名稱(chēng)	規格	單位	單價(jià)
HaoKebio	HKZ150195	Cytokeratin 1兔單克隆抗體	100ul	支	600

Cytokeratin?1
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50072?Clone# ?BP6077
Predicted?Molecular Wt:
66kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P04264
Background:
Cytokeratin?1?may?regulate the activity of?kinases such as?PKC?and?SRC?via?binding?to?integrin?beta-1?(ITB1)?and?the?receptor?of?activated?protein?kinase?C?(RACK1/GNB2L1).
Defects?in Cytokeratin?1 area cause of?bullous?congenital?ichthyosiformerythroderma?(BCIE);?also?known?as?epidermolytic?hyperkeratosis?(EHK) or?bullouserythroderma?ichthyosiformiscongenita of?Brocq.?BCIE?is an autosomal?dominant?skin
disorder characterized?by widespread?blistering and anichthyoticerythrodermaat?birth that?persist?into?adulthood.
Histologically there?is a diffuse epidermolytic degeneration?in?the?lower?spinouslayer?of the?epidermis.?Within?a?few?weeks?from?birth, erythroderma and?blister formation diminish?and?hyperkeratoses develop.
In diagnostic?pathology,?immunohistochemical detection of cytokeratin?1?is?usually?used to?labelsquamous,?ductaland
complex epithelia combined with other?high?molecular weight?cytokeratins?such?as?cytokeratins?5,?10?and?14.?Resultsaid?in?the classification of?prostatic adenocarcinoma and?in the?classification?of?neoplastic?tissue?as?carcinoma?of?epithelial?origin.
Subcellular?location:
Plasma?membrane, cytoplasm
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen: ?
Synthetic?peptide?corresponding?to?residues?withinaa200-300 of??Cytokeratin?1 was?used?as?an?immunogen.
Background?References:
1.?Schaller G et al.?Immunohistochemical detection?of?keratins
1 and?13 as?differentiation?markers?in?the?hormone-?????dependent?human vaginal epithelium.?Gynecol Obstet?Invest.?1990;30(2):94-6.
2.Murakami?Y,?et?al.?Immunohistochemical?interpretation?of?early?epithelial?disorders?of?pyriform?sinus.?Ann?Otol?RhinolLaryngol.?1990 Oct;99(10?Pt?1):782-8.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA
0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Immunohistochemistry
(Formalin/PFA-fixed
paraffin-embedded
sections analysis?of
esophagus tissue
labelling Cytokeratin?1?with?BP6077.?Heat
mediated?antigen
retrieval?was?performed
using Tris/EDTA?buffer?pH?9.0.

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