• CTLA-4兔單克隆抗體

    CTLA-4兔單克隆抗體

    • 價(jià)格￥1800
    • 規格100ul
    • 貨號HKZ150333
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150333CTLA-4兔單克隆抗體100ul支1800
    CTLA-4
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    Catalog# ?BX50210?Clone# ?BP6187
    Predicted?Molecular Wt:
    25kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID: ??P16410
    Background:
    Cytotoxic T?lymphocyte-associated antigen-4?(CTLA-4)?is a?member of the CD28?superfamily?and?is?a?negative?regulator?of T
    cell-mediated?immune?responses. CTLA-4 expression?is?induced on the surface?of T?cells?after?CD28?binding?and?activation,
    and?is constitutively expressed on T-regulatory cells,?acting?as?an?immune?checkpoint?inhibitor,?downregulating T?cell?activity.
    CTLA-4?primarily?inactivates T-cell activity?by competing with the CD28?costimulatory?molecule.?CD28?and?CTLA-4?share?the?identical?ligands?of?CD80 and?CD86?on?antigenpresenting?cells;?and?thus?CTLA-4?competes?with?CD28?function?in?T-cell
    survival,?proliferation, and?recruitment.?In?particular, CTLA-4 down-modulates CD4+?helper T-cell?activity?and?enhances Treg??immunosuppressive functions. CTLA-4?has?been shown to?play a?role?in?human?diseases.?CTLA-4?acts?as?a?physiological?brake?on the activated?immune system?in order to?maintain?immune?homeostasis.?Several?suppressive?mechanisms for T-cell
    functions?have?been attributed to CTLA-4.
    Subcellular?location:
    Membrane
    Recommended?method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Synthetic?peptide within?Human CTLA-4.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage conditions:
    -25°C?to?-18°C
    Storage instructions:
    Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
    Recommended?Dilutions:
    IHC-P:?????1:100-1:200
    Background?References:
    1. ?Buchbinder?EI,?McDermott?DF.?Clinical?Therapeutics.?2015;?37:755-63.
    2.?Scalapino?KJ,?Daikh?DI.?Immunol?Rev.?2008 Jun;223:143-55.
    Immunohistochemistry?(Formalin/PFA-fixed
    paraffin-embedded
    sections)?analysis
    of ?human??tonsil?tissue?labelling?CTLA-4?with
    BP6187.?Heat?mediated antigen?retrieval?was
    performed?using
    Tris/EDTA?buffer?pH?9.0

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