• ATRX兔單克隆抗體

    ATRX兔單克隆抗體

    • 價(jià)格￥1000
    • 規格100ul
    • 貨號HKZ150348
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150348ATRX兔單克隆抗體100ul支1000
    ATRX
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    Catalog# ?BX50225?Clone# ?BP6202
    Predicted?Molecular Wt:
    283kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID: ??P46100
    Background:
    α-thalassemia/mental?retardation X-linked?(ATRX)?is a transcriptional?regulator and?helicase that?belongs to the?SNF2 family??of chromatin?remodeling?proteins. Together with?its?binding?partner death-associated?protein?6?(Daxx), ATRX acts?as?histone?chaperone to deposit?histone variant?H3.3 at?repetitive?DNA sequences such?as?telomeric,?pericentric,?and?ribosomal?gene?????repeats. ATRX?is?involved?in?many?nuclear functions that ensure?proper sister chromatid?cohesion?during?mitosis?and
    chromosome alignment during?meiosis. The ATRX transcriptional?regulator also?plays?a?role?in?the?maintenance?of telomere???integrity and the?regulation of gene expression?during?mammalian?development?by?influencing?DNA?methylation?patterns?at?high?DNA?repeat sequences.?Mutations?in the corresponding ATRX gene?results?in ATR-X?syndrome,?an?X-linked?disorder
    characterized?by?intellectual disabilities, craniofacial abnormalities, and?mild?α-thalassemia.
    Subcellular?location:
    Nuclear
    Recommended?method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Recombinant?protein fragment within?Human ATRX.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage conditions:
    -25°C?to?-18°C
    Storage instructions:
    Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
    Recommended?Dilutions:
    IHC-P:?????1:100-1:200
    Background?References:
    1.?Schwartzentruber, J. et?al.?(2012)?Nature?482,?226-31.
    2. ?Els?sser, S.J. et?al.?(2012)?Nature?491,?560-5.
    Immunohistochemistry?(Formalin/PFA-fixed
    paraffin-embedded?sections)?analysis of?human
    breast?carcinoma tissue
    labelling?ATRX?with?BP6202.?Heat?mediated?antigen
    retrieval?was?performed????using Tris/EDTA?buffer?pH?9.0

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