- 價(jià)格￥2200
- 規格100ul
- 貨號HKZ150260
- 單位支
- 品牌HaoKebio
| 品牌 | 商品編碼 | 商品名稱(chēng) | 規格 | 單位 | 單價(jià) |
|---|
| HaoKebio | HKZ150260 | PD-L1兔單克隆抗體 | 100ul | 支 | 2200 |
|---|
PD-L1
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50137?Clone# ?BP6141
Predicted?Molecular Wt:
33kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID:??Q9NZQ7
Background:
Programmed?cell?death?ligand?1?(PD-L1) also?known?as?cluster?of?differentiation?274?(CD274)?or?B7?homolog?1?(B7-H1)?is?a?type?1?transmembrane?protein?involved?in the?regulation of cellular and?humoral?immune?responses. The?interaction?of?PD-L1 with?its???receptor?PD-1?provides?both stimulatory and?inhibitory signals?in?regulating T cell?activation?and?tolerance?during?pregnancy
tissue allografts, autoimmune disease and?malignant transformation.
PD-L1?is?expressed?on?resting?T?cells,?B?cells,?DCs,?and?macrophages?and?is?further?up-regulated?upon?activation.?PD-L1?is?also
expressed on?parenchymal cells,?including vascular endothelial?cells and?pancreatic?islet?cells.?The?expression?of?PD-L1?has?been????discovered?in avariety of epithelial cancers?such?as?non-small?cell?lung?carcinoma?(NSCLC),?pancreatic?cancer,?esophageal?cancer,?squamous cell carcinomas of the?head and?neck,?and?renal?cell?carcinoma?(RCC).
The?use of?IHC for?protein?identification, along with?novel therapies, such?as?checkpoint?inhibitors?and?vaccines,?are?generating?new options for the treatment of?cancer?patients.
Subcellular?location:
Membrane
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Recombinant full?length?protein corresponding to
Human?PD-L1?(extracellular). The?immunogen?contains the?specific?extracellular?domain?of?huPD-L1?(F19-
T239).
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1. ?MuenstS1, et?al.?Breast?Cancer?Res?Treat.?2014?Jul;146(1):15-24.
2. ?Lim?SH, et?al.?Expert?Opin?Biol?Ther.?2016;16(3):397-?406.
Immunohistochemistry
(Formalin/PFA-fixed
paraffin-embedded
sections analysis?of
placenta tissue?labelling
PD-L1 with?BP6001.?Heat ???mediated?antigen?retrieval?was?performed?using
Tris/EDTA?buffer?pH?9.0
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