• Desmin兔單克隆抗體

    Desmin兔單克隆抗體

    • 價(jià)格￥600
    • 規格100ul
    • 貨號HKZ150262
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150262Desmin兔單克隆抗體100ul支600
    Desmin
    Mouse?Monoclonal Antibody?Product?Datasheet
    Catalog# ?BX50139?Clone# ?D33
    Predicted?Molecular Wt:
    53kDa
    Purity: ??ProG?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID: ??P17661
    Background:
    Desminis a?53kDa?intermediate filament?(IF)?protein that?integrates the sarcolemma, Z?disk,?and?nuclear?membrane?in
    sarcomeres and?regulates sarcomere architecture.?Desmin?play?no?role?in contractility?but?serves to?maintain the?orientation?of?actin and?myosin filaments and?may also?play?a?role?in?nuclear transcription.
    Desminis expressed?in all striated?muscle cells?and?most?smooth?muscle?cells.?In the?developing?striated?muscle?cells?it?replaces?vimentin,?linked to the Z-disc.?In the smooth?muscle cells desminis?associated?with?cytoplasmic?dense?bodies?and
    subplasmalemmal dense?plaques.?In?myofibroblasts and vascular smooth?muscle cells?desminis?co-expressed?with?vimentin.
    However,?in the arterial smooth?muscle cells, desmin?may?be?scarce?or?absent,?while?vimentin?expression?is?retained.?Mesothelial?cells?may express desmin,?particularly?in effusions and?cultures.?In?tumor?tissues,?it?detected?in?leiomyomas,?leiomyosarcoma,
    rhabdomyomas,?rhabdomyosarcoma, and?perivascular cells of glomus tumors of the?skin.
    Desminis?used?in a?panel for?identification of?leiomyosarcoma,?rhabdomyosarcoma and?other tumours with?myoid?differentiation, and for classification of?mesenchymal,?pleomorphic,?spindle cell?and?round?cell?neoplasms.
    Subcellular?location:
    Cytoplasm
    Recommended?method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Immunogen derived from?human?Leiomyoma
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage conditions:
    -25°C?to?-18°C
    Storage instructions:
    Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
    Recommended?Dilutions:
    IHC-P:?????1:100-1:200
    Background?References:
    1. ?Brodehl?A., et?al.?Circ?Cardiovasc?Genet.?2013?Dec;6(6):615-23.
    2.?Colella?R., et?al. Am?J?Surg?Pathol.?2010 Jan;34(1):10-7.
    Immunohistochemistry
    (Formalin/PFA-fixed
    paraffin-embedded
    sections)?analysis of
    esophagus tissue?labelling?Desmin?with?D33.?Heat
    mediated?antigen?retrieval?was?performed?using
    Tris/EDTA?buffer?pH?9.0

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