• GFAP兔單克隆抗體

    GFAP兔單克隆抗體

    • 價(jià)格￥600
    • 規格100ul
    • 貨號HKZ150179
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150179GFAP兔單克隆抗體100ul支600
    GFAP
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    Catalog# BX50056?Clone# ?BP6061
    Predicted?Molecular Wt:
    50kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID: ??P14136
    Background:
    GFAP?(Glial fibrillary acidic?protein)?is an?intermediate filament?protein. The?protein?is the smallest?(8?nm)?of the?intermediate?filament?proteins with a?molecular weight of?about?50?kDa.
    In the central?nervous system, GFAP?is expressed?in?astrocytes?andependymal?cells?but?not?in?other?glial?cells.?However,
    immature oligodendrocytes and?immature choroid?plexus cells?may?be GFAP?positive.?In?the?peripheral?nervous?system?enteric?Schwann cells and satellite cells?of?human?sensory?ganglia?express?GFAP.?Outside?the?nervous?system,?GFAP?is?seen?in
    myoepithelial cells and chondroblasts.?In tumor tissues,?astrocytoma,?ependymoma, glioblastoma,?and?oligodendroglioma?are?almost always?positive.?Plexus carcinoma, ganglioglioma and?primitive?neuroectodermal tumors?(PNET:?neuroblastoma?a.o.)?????express GFAP to a varying extent.?Schwannoma?and?neurofibroma frequently?express?GFAP.?Chondroma,?chondrosarcoma
    and?pleomorphic adenoma are also GFAP?positive?in?most?cases.?A?few?carcinomas?(especially?from?lung?and?breast)?may?express GFAP?in?paraganglioma GFAP?may?be detected?in sustentacular?cells.
    GFAP?is?used to differentiate astrocytoma from?non-glial cell?tumors.
    Subcellular?location:
    Cytoplasm
    Recommended?method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Synthetic?peptide corresponding to GFAP?residues
    within?aa332-432 of??GFAP?was?used?as?an?immunogen.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage conditions:
    -25°C?to?-18°C
    Storage instructions:
    Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
    Recommended?Dilutions:
    IHC-P:?????1:100-1:200
    Background?References:
    1. ?McLendon?RE, et?al.?Brain?Tumor?Pathol.?2002;19(2):51-8.?Review.
    2. ?Matyja?E, et?al.?Folia?Neuropathol.?2001;39(1):19-26.
    Immunohistochemistry?(Formalin/PFA-fixed
    paraffin-embedded
    sections analysis?of
    astrocytoma tissue
    labelling GFAP?with
    BP6061.?Heat?mediated antigen?retrieval?was
    performed?using
    Tris/EDTA?buffer?pH?9.0

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