杭州浩克生物SOX-11兔單克隆抗體
675Tested Applications: WB, ELISA Cited Applications: WB Species Specificity: human Cited Species: human Pos...
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| 品牌 | 商品編碼 | 商品名稱(chēng) | 規格 | 單位 | 單價(jià) |
|---|---|---|---|---|---|
| HaoKebio | HKZ150140 | Cytokeratin 19兔單克隆抗體 | 100ul | 支 | 600 |
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
?
Catalog# ?50017?Clone# ?BP6022
?
Predicted?Molecular Wt:
44kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P08727
Background:
Cytokeratin?19?is the smallest?keratin and?is exceptional since?it?widely?lacks the?non–helical?tail?domain?typical?for?all?other?keratins.?It?may?have evolved from?keratinocyte?keratins.
?
Cytokeratin?19?is expressed?in?most simple epithelia?(excluding?parenchymatous cells?such?as?hepatocytes,?pancreatic?acinar
cells, and?renal?proximal tubular cells),?notably?in various ductal?epithelia,?in?small?and?large?intestinal?epithelium,?in?gastric
foveolar epithelium, and?in?mesothelium.?Furthermore,?it?is?present?in?most cells of?pseudostratified?epithelia?and?urothelium???as well as?in?basal cells of?non-keratinizing stratified?squamous?epithelium.?In?carcinomas,?cytokeratin?19?is?widely?expressed?in?both adenocarcinomas and squamous cell?carcinomas?and therefore?is?not?extensively?used?as?an?immunohistochemical
marker for carcinoma?subtyping.
?
Cytokeratin?19?is?not expressed?in?most?hepatocytes, therefore cytokeratin?19?is?useful?in the?identification of?liver?metastasis?and can?be?used?in a?panel with?Hepatocyte Specific?Antigen.
?
Subcellular?location:
Cytoplasm
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to cytokeratin?19
residues?within?aa1‐100 of?cytokeratin?19?was?used?as an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Immunohistochemistry?(Formalin/PFA-fixed
paraffin-embedded
sections)?analysis of?human?thyroid cancer tissue
labelling?cytokeratin?19?with?BP6022.?Heat
mediated?antigen?retrieval?was?performed?using
Tris/EDTA?buffer?pH?9.0
Background?References:
1. ?Barroeta?JE, et.al,Endocr?Pathol.?2006?Fall;17(3):225-?34.2.?Schmitt?AM, et.al,Am?J?Surg?Pathol.?2007?Nov;31(11):1677-82.
上一篇: Cytokeratin 5兔單克隆抗體下一篇: CDX2兔單克隆抗體
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