SNF5兔單克隆抗體

價(jià)格￥1800
規格100ul
貨號HKZ150409
單位支
品牌HaoKebio

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產(chǎn)品參數

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品牌	商品編碼	商品名稱(chēng)	規格	單位	單價(jià)
HaoKebio	HKZ150409	SNF5兔單克隆抗體	100ul	支	1800

SNF5
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# BX50286?Clone# ?BP6263
Predicted?Molecular Wt:
44kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID:??Q12824
Background:
SNF5, one of the core subunits?of the?SWI/SNF?complex,?is?necessary for?efficient?nucleosome?remodeling?by?BRG1?in?vitro.
SMARCB1/BAF47?is an essential?part of the esBAF?(mouse?embryonic?stem?cell?specific?SWI/SNF?complex)?and?is?necessary?for?early embryogenesis and?hepatocyte differentiation.?In addition,?SNF5?is?considered to?be?a?tumor?suppressor?protein;
inactivating?mutations?have?been?indentifiedina?large?number of?malignant?rhabdoid tumors.
SNF5?is widely expressed?in?normal tissues and tumor tissues,?but?is?often?absent?in?malignant?rhabdomyosarcoma?and?epithelioid sarcoma.
SNF5 antibodies?have?been?used?to distinguish?between atypical teratoid/rhabdomyosid tumors?(SNF5?deletion)?and?choroid?plexus carcinoma?(SNF5?positive), and?between epithelioid sarcoma?(SNF5?deletion)?and?epithelioid?hemangioendothelioma??(SNF5?positive).
Subcellular?location:
Nucleus
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Recombinant?protein fragment of SNF5 was?used?as an?immunogen. This?information?is?proprietary to?Biolynx.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1. ?Ho,?L. and?Crabtree, G.R.?(2010)?Nature?463, 474-84.
2. ?Klochendler-Yeivin, A. et?al.?(2000)?EMBO?Rep?1,?500-6.
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-embedded?sections)?analysis of ?human epithelioid?sarcoma?labelling?SNF5??with?BP6263.

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