• MHC Ⅱ(DR α chain)兔單克隆抗體

    MHC Ⅱ(DR α chain)兔單克隆抗體

    • 價(jià)格￥1800
    • 規格100ul
    • 貨號HKZ150315
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150315MHC Ⅱ(DR α chain)兔單克隆抗體100ul支1800
    MHC?Ⅱ(DR?α?chain)
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    Catalog# ?BX50192?Clone# ?BP6170
    Predicted?Molecular Wt:
    29kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID: ??P01903
    Background:
    Major?histocompatibility complex class?II?(MHC class?II)?molecules are?heterodimeric, transmembrane?glycoproteins?expressed
    on the surface of antigen-presenting cells?such?as?macrophages,?dendritic?cells,?and?B?cells.?Expression?can?also?be?induced?on?other cell types through?interferon-γ signaling.?Prior to?being displayed?on?the?cell?membrane,?MHC?class?II?molecules?are
    loaded with exogenous?peptide antigens approximately?15-24 amino?acids?in?length?that?were?derived?from?endocytosed?extracellular?proteins digested?in the?lysosome. Antigen-presentation through?MHC class?II?is?required for T?cell?activation?during the?immune?response to extracellular?pathogens.?In?humans, the?MHC class?II?protein complex?is?encoded?by?the????human?leukocyte antigen gene complex?(HLA).
    Subcellular?location:
    Membrane
    Recommended?method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Synthetic?peptide?near?N-terminal?residues?in?Human?MHC?Ⅱ(DR?α chain) was?used?as?an?immunogen.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage conditions:
    -25°C?to?-18°C
    Storage instructions:
    Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
    Recommended?Dilutions:
    IHC-P:?????1:100-1:200
    Background?References:
    1.?Temponi,?M. et?al. J?Immunol?Methods?161?(1993)?.
    2.?Ting, J.P. and?Trowsdale, J. Cell?109?Suppl?(2002)?.
    Immunohistochemistry?(Formalin/PFA-fixed
    paraffin-embedded
    sections)?analysis of?human?colorectal?carcinoma tissue
    labelling?DR?α chain?of
    MHC?Ⅱ with?BP6170.?Heat mediated?antigen?retrieval??was?performed?using
    Tris/EDTA?buffer?pH?9.0

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