- 價(jià)格￥2200
- 規格100ul
- 貨號HKZ150394
- 單位支
- 品牌HaoKebio
| 品牌 | 商品編碼 | 商品名稱(chēng) | 規格 | 單位 | 單價(jià) |
|---|
| HaoKebio | HKZ150394 | PRAME兔單克隆抗體 | 100ul | 支 | 2200 |
|---|
PRAME
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50271?Clone# ?BP6248
Predicted?Molecular Wt:
58kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P78395
Background:
Cancer/testis antigens?(CTAs) area family of?more than?100?proteins whose?normal?expression?is?largely?restricted?to?immune?privileged germ cells of the testis, ovary,?and trophoblast?cells?of the?placenta.?Although?most?normal?somatic?tissues?are?void?of CTA expression, due to epigenetic?silencing?of gene?expression,?their?expression?is?upregulated?in?a?wide?variety?of?human???solid and?liquid tumors.
PRAME?(preferentially expressed antigen?in?melanoma)?is a cancer/testis?antigen?not?normally?expressed?in?any?tissues?except?testis,?but?is?upregulated?in tumors.?PRAME?is expressed?in?melanoma cells and?is?recognized?by?cytolytic T-cells.?It?is?also
upregulated?in other diseases, such as?synovial?sarcoma,?NSCLC,?and?breast?cancer,?where?it?is?thought?to?contribute?to
tumorigenesis and?metastasis.?PRAME?is also?highly expressed?in?liquid tumors such?as?AML?and?can?be?predictive?of?clinical?outcome?in some circumstances.
PRAME and other cancer/testis antigens?are?currently?being?pursued?as?novel?immunotherapy?targets?and?diagnostic?biomarkers.
Subcellular?location:
Nucleus
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Recombinant?protein fragment of?human?PRAME was?used as?an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1.?Qin, Y.Z.?et?al.?(2017) Oncol?Lett?13,?2823-2830.
2. ?Iura,?K.?et?al.?(2017)?Hum?Pathol?61,?130-139.
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-?embedded?sections)?analysis of ?human
malignant?melanoma?labelling?PRAME?with?BP6248.
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