• CDK4兔單克隆抗體

    CDK4兔單克隆抗體

    • 價(jià)格￥1000
    • 規格100ul
    • 貨號HKZ150376
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150376CDK4兔單克隆抗體100ul支1000
    CDK4
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    Catalog# ?BX50253?Clone# ?BP6230
    Predicted?Molecular Wt:
    34kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID: ??P11802
    Background:
    Cyclin-dependent?kinase-4?(CDK4)?is a?protein-serinekinase?involved?in the cell cycle.?It?is essential?for?the?G1- to?S-phase
    transition?during?the?cell?cycle?and?its?expression?is?primarily?controlled?at?the?transcriptional?level?(PMID:17253961).?CCND1-?CDK4 axis?is?not only critical?in glial tumor?cells?but?also?in?stromal-derived?cells?in?the?surrounding?tumor?microenvironment???that?are?vital?to?sustain?tumor?outgrowth?(PMID:21844184).
    CDK4?is?highly expressed?in?highly?differentiated and dedifferentiated?liposarcomas,?but?rarely expressed?in?other?benign?liposarcomas and other?sarcomas.
    CDK4 and?MDM2 combined to differentiate?between?highly?differentiated?liposarcoma?(+),?dedifferentiated?liposarcoma?(+)?and?myxoid?liposarcoma,?pleomorphic?liposarcoma, spindle?lipoma,?pleomorphic?lipoma and other?high-grade sarcomas.
    Subcellular?location:
    Nucleus
    Recommended?Method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    A synthetic?peptide corresponding to the?N-term of?CDK4 was?used as?an?immunogen.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage Conditions:
    -25°C?to?-18°C
    Shipment?Instructions:
    Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
    Recommended?Dilution:
    IHC-P:?????1:100-1:200
    Background?References:
    1.??Ma?L??etal. ?Oncotarget?8:4125-4135?(2017).
    2. ?Lv?XJ??et?al.?Oncol?Rep?N/A:N/A?(2016).
    Immunohistochemistry?(Formalin/PFA-fixed?paraffin-?embedded?sections)?analysis of dedifferentiated
    liposarcoma?labelling?CDK4 with?BP6230.

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