• c -Myc兔單克隆抗體

    c -Myc兔單克隆抗體

    • 價(jià)格￥1000
    • 規格100ul
    • 貨號HKZ150341
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150341c -Myc兔單克隆抗體100ul支1000
    c-Myc
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    Catalog# ?BX50218?Clone# ?BP6195
    Predicted?Molecular Wt:
    48kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID: ??P01106
    Background:
    Oncogene-encoded?proteins c-Myc,?n-Myc, and?l-Myc function?in cell?proliferation,?differentation?and?neoplastic?disease. A?mutated version of?Myc?is found?in?many cancers, which?causes?Myc to?be?constitutively?expressed. This?leads?to?the
    unregulated expression of?many genes, some?of which?are?involved?in?cell?proliferation,?and?result?in?the?formation?of?cancer.?c-Myc?is a transcription factor and?is a?proto-oncogene that?is?the?focal?point?in?cell?cycle?regulation,?metabolism,?apoptosis,????differentiation, cell adhesion, and tumorigenesis.
    A common?human translocation?involving?Mycist(8;14), which?is criticialto the development?of?most?cases?of?Burkitt’s?Lymphoma.?Malfunctions?in?Myc?have also?been found?in carcinoma of the?cervix,?colon,?breast,?lung,?and?stomach.
    Subcellular?location:
    Nucleus
    Recommended?method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Synthetic?peptide?residues?in?human c-Myc was?used?as an?immunogen.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage conditions:
    -25°C?to?-18°C
    Storage instructions:
    Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
    Recommended?Dilutions:
    IHC-P:?????1:100-1:200
    Background?References:
    1.??Hoffman?B, et?al. Oncogene.?2002;?21(21):3414-21.
    2. ?Nakles?R, et?al.?Mol?Endocrinol.?2011;?25:549-63.
    Immunohistochemistry?(Formalin/PFA-fixed
    paraffin-embedded?sections)?analysis?????of?human?Burkitt’s
    lymphoma tissue?labelling??c-Myc?with?BP6195.?Heat ???mediated?antigen?retrieval?was?performed?using
    Tris/EDTA?buffer?pH?9.0

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