• TdT兔單克隆抗體

    TdT兔單克隆抗體

    • 價(jià)格￥1000
    • 規格100ul
    • 貨號HKZ150207
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150207TdT兔單克隆抗體100ul支1000
    TdT
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    Catalog# ?BX50084?Clone# ?BP6089
    Predicted?Molecular Wt:
    58kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID: ??P04053
    Background:
    Terminal deoxynucleotidyl transferase?(TdT)?is an?unusual deoxynucleotide?polymerizing enzyme?with?a?molecular?weight?of???about?58?kDa found?normally only?in?B- and T-cell?lymphoblasts/prelymphocytes. TdT generates antigen?receptor?diversity?by?synthesizing?non-germline elements?(N-regions) at the junctions of?rearranged?Ig?heavy chain?and T?cell?receptor?gene
    segments.Rare TdT-positive cells are?regularly detected?in thymus and?bone?marrow.?Typically,?TdT?expression?in?the?thymus?is
    very variable from cell to cell since?it?is?rapidly?decreased?in?more?mature T-cells.?Tdt-positive?cells?may?occasionally?be?found?in tonsils,?lymph?nodes and extranodal?lymphoid tissue.?Immunohistochemical detection?of TdT?has value?in?classification?of???malignant?lymphomas and acute?leukaemias,?particularly for the?identification of?pre-B?and?pre-T?acute?lymphoblastic
    leukemia/lymphoblastic?lymphoma?(ALL/LBL).
    ?Subcellular?location:
    Nucleus
    Recommended?method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Synthetic?peptide corresponding to?residues within?aa1-100 of?TdT?was?used?as?an?immunogen.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage conditions:
    -25°C?to?-18°C
    Storage instructions:
    Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
    Recommended?Dilutions:
    IHC-P:?????1:100-1:200
    Background?References:
    1.?Chang?LM,?Bollum?FJ.?CRC?Crit?Rev?Biochem.?1986;21(1):27-52.
    2. ?Kang?LC,?Dunphy?CH. Arch?Pathol?Lab?Med.?2006;130(2):153-7.
    Immunohistochemistry?(Formalin/PFA-fixed
    paraffin-embedded
    sections)?analysis of
    thymoma?labelling TdT?with?BP6089.?Heat
    mediated?antigen
    retrieval?was?performed?using Tris/EDTA?buffer????pH?9.0.

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