• Beta -Catenin兔單克隆抗體

    Beta -Catenin兔單克隆抗體

    • 價(jià)格￥1000
    • 規格100ul
    • 貨號HKZ150304
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150304Beta -Catenin兔單克隆抗體100ul支1000
    Beta-Catenin
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    Catalog# ?BX50181?Clone# ?BP6159
    Predicted?Molecular Wt:
    86kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID: ??P35222
    Background:
    Beta-Catenin?is a?key?regulatory?protein?in Wnt signaling,a?pathway that transmits signals?from?the?cytoplasm?to?the?nucleus,?turning on the expression of specific?genes?in?the?nucleus.Under?normal?conditions,?Beta-Catenin?exists?mainly?in?the?cell
    membrane of?normal cells, and gene?mutations?lead to?accumulation?in?the?nucleus.?At?present,?Beta-Catenin?gene?mutation?has?been found?in various tumors, such as colon?cancer,?lung?cancer,?prostate?cancer,?esophageal?cancer,?breast?cancer,?ovarian
    cancer, endometrial cancer,familial adenomatous?polyposis, solid?pseudopapilloma?of?pancreas,?etc.?High?levels?of?nucleus
    positivityare seen?in desmoid fibromatosis,?isolated fibrous tumors, synovial?sarcomas?and?endometrial?stromal?sarcomas,?and?carcinosarcomas.?It?is?mainly?used for the diagnosis,?invasion and?metastasis of?malignant tumor.
    Subcellular?location:
    Membrane?&?Cytoplasm?&?Nucleus
    Recommended?method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Synthetic?peptide corresponding to?Human?Beta-?Catenin was?used as an?immunogen. The?exact
    sequence?is?proprietary.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage conditions:
    -25°C?to?-18°C
    Storage instructions:
    Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
    Recommended?Dilutions:
    IHC-P:?????1:100-1:200
    Background?References:
    1. ?Li?XG??et?al. Toxicol?Lett?305:19-31?(2019).
    2.?Xu?H??etal. Oncol?Rep?41:1180-1188?(2019).Immunohistochemistry?(Formalin/PFA-fixed
    paraffin-embedded?sections?analysis?of
    human??prostate ?tissue
    labelling?Beta-Catenin?with?BP6159.?Heat?mediated
    antigen?retrieval was
    performed?using Tris/EDTA
    buffer?pH?9.0

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