• Podoplanin兔單克隆抗體

    Podoplanin兔單克隆抗體

    • 價(jià)格￥1000
    • 規格100ul
    • 貨號HKZ150228
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150228Podoplanin兔單克隆抗體100ul支1000
    Podoplanin
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    Catalog# ?BX50105?Clone# ?BP6110
    Predicted?Molecular Wt:
    17kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID:??Q86YL7
    Background:
    Podoplanin was first?identified as a transmembrane glycoprotein?in the?podocytes?of?rat?kidney.?Podoplanin?acts?as?receptor?for selectins?(which?mediate?inflammatory cell adhesion) and?is?involved?in?cell?maturation?and?migration?by?filopodia
    formation?(via the downregulation of the activities of?small?Rho?family?GTPases).
    Podoplanin?is found?in?lymphatic endothelium?(but?not?bloodvessel endothelium), fibroblasts, osteocytes, follicular?dendritic??cells, smooth and striated?muscle cells,?myoepithelial?cells,?Cajal?cells,?basal?cells?in?squamous?epithelium?(tonsil),?gastric?crypt?cells,?prostatic?basal cells,?immature Sertoli cells and foetal?gonocytes?(but?not the?corresponding?cells?of the?adult?testis),
    renal glomerular?podocytes,?mesothelium?(particularly when?reactive), subsets of?lymphocytes, Schwann?cells,?glial?and?ependymal cells.
    Podoplanin?is a very?useful?marker?in the differentiation?between?malignant?mesothelioma and?adenocarcinoma,?and the?identification of seminoma/dysgerminoma/IGCN.
    Subcellular?location:
    Membrane
    Recommended?method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Synthetic?peptide corresponding to?residues within??aa1-100 of?Podoplanin?was?used?as?an?immunogen.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage conditions:
    -25°C?to?-18°C
    Storage instructions:
    Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
    Recommended?Dilutions:
    IHC-P:?????1:100-1:200
    Background?References:
    1. ?Bassarova?AV, Am?J?Surg?Pathol.?2006 Jul;30(7):878-82.
    2. ?Biermann?K,?Histopathology.?2006 Sep;49(3):290-7.
    Immunohistochemistry?(Formalin/PFA-fixed
    paraffin-embedded
    sections)?analysis of?lung??labelling?Podoplanin with?BP6110.?Heat?mediated ???antigen?retrieval was
    performed?using
    Tris/EDTA?buffer?pH?9.0.?

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