Cytokeratin 17兔單克隆抗體

價(jià)格￥600
規格100ul
貨號HKZ150226
單位支
品牌HaoKebio

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品牌	商品編碼	商品名稱(chēng)	規格	單位	單價(jià)
HaoKebio	HKZ150226	Cytokeratin 17兔單克隆抗體	100ul	支	600

Cytokeratin?17
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50103?Clone# ?BP6108
Predicted?Molecular Wt:
48kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID:??Q04695
Background:
Cytokeratin?17?(CK17) is?48?kD?intermediate?filament?found?in?simple?epithelia?and?is?a?marker?for?cervical?reserve?(stem)?cells.?CK17 can?be?useful?in the?identification of?uterine cervical squamous?lesions?including?atypical?immature?metaplasia,?cervical????intraepithelial?neoplasia, and cervical squamous carcinoma.?CK17?also?assists?in the?differentiation?of?oralsquamous?cell
carcinoma. CK17 staining occurs?in?human epithelial?appendages?such?as?hair?follicles.
Studies?indicate CK17?maybe an excellent?marker for the?identification?of squamous?cell?carcinomas?in?various?tissues
including the cervix,?lung and oral cavity.?CK17?may?also?be?helpful?in?distinguishing?myoepithelial?cells?from?luminal
epithelium of various glands such as?mammary,?sweat?and?salivary.?Positive?expression?of CK17?in?breast?cancer?has?been????associated with a worse?prognosis,?high tumor grade and?positive?axillary?lymph?nodes.?Expressed?in?the?outer?rootsheath?and?medulla?region of?hair follicle specifically from eyebrow?and?beard,?digital?pulp,?nail?matrix?and?nail?bed?epithelium,
mucosal stratified squamous epithelia and?in?basal?cells?of?oral?epithelium,?palmoplantar?epidermis?and?sweat?and?mammary?glands. Also expressed?in?myoepithelium of?prostate,?basal?layer of?urinary?bladder,?cambial?cells of?sebaceous?gland?and?in????exocervix?(at?protein?level).
Subcellular?location:
Cytoplasmic
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to?residues within??aa400-500 of?Human?Cytokeratin?17 was?used?as?an immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1.?vande?Rijn?M, et?al. Am?J?Pathol.?2002?Dec;?161(6):1991-6.
2. ?Lerma?E,?Barnadas?A,?Prat?J. Appl?Immunohistochem?Mol Morphol.?2009?Dec;?17(6):483-94.
Immunohistochemistry?(Formalin/PFA-fixed
paraffin-embedded?sections analysis
of ?esophageal
carcinoma tissue
labelling?Cytokeratin?17?with?BP6108.?Heat
mediated?antigen
retrieval?was?performed?using Tris/EDTA?buffer

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