• Cytokeratin 6兔單克隆抗體

    Cytokeratin 6兔單克隆抗體

    • 價(jià)格￥600
    • 規格100ul
    • 貨號HKZ150183
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150183Cytokeratin 6兔單克隆抗體100ul支600
    Cytokeratin?6
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    Catalog# ?BX50060?Clone# ?BP6065
    Predicted?Molecular Wt:
    60kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID: ??P48668
    Background:
    Cytokeratin?6?is an epidermis-specific type?I?keratin?involved?in wound?healing.?Involved?in the?activation?of follicular
    keratinocytes after wounding, while?it does?not?play a?major?role?in?keratinocyte?proliferation?or?migration.?This?protein?always?paired?with?the?type-I?keratin?K16.
    Cytokeratin?6?have?been?identified?in?epidermis only?in?samples from?plantar glabrous skin while?in?hairy?skin?this?keratin
    appeared to?be absent?in?interfollicular epidermis?but were clearly?present?in?hair follicle?outer?rootsheath,?and?this?protein?also consistently expressed?in?non-keratinizing stratified squamous?epithelia. Among?tumors,?cytokeratin?6?is typically?and?????strongly expressed?in squamous cell carcinomas?of?different?sites,?preferentially?in?inner,?maturing?layers?of the tumor?cell?????nests.
    Cytokeratin?6?is always?used with cytokeratin 5?and?is?a?useful?aid for?classification?of?epithelioid?mesotheliomas.
    Subcellular?location:
    Cytoplasm
    Recommended?method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Synthetic?peptide corresponding to?Cytokeratin 6
    residues?within?aa464-564 of??Cytokeratin?6?was?used as an?immunogen.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage conditions:
    -25°C?to?-18°C
    Storage instructions:
    Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
    Recommended?Dilutions:
    IHC-P:?????1:100-1:200
    Background?References:
    1. ?R?Mollet?al.?Histochem?Cell?Biol?(2008)?129:705–733.
    2. ?R?Mollet?al.?Cell, Vol.?31,?1?l-24,?November?1982.
    Immunohistochemistry?(Formalin/PFA-fixed
    paraffin-embedded
    sections analysis?of
    esophagus?cancer tissue?labelling Cytokeratin?6????with?BP6065.?Heat
    mediated?antigen
    retrieval?was?performed?using Tris/EDTA?buffer????pH?9.0

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