• Cytokeratin 14兔單克隆抗體

    Cytokeratin 14克隆抗體

    • 價(jià)格￥600
    • 規格100ul
    • 貨號HKZ150170
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150170Cytokeratin 14兔單克隆抗體100ul支600
    Cytokeratin?14
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    Catalog# ?BX50047?Clone# ?BP6052
    Predicted?Molecular Wt:
    52kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID: ??P02533
    Background:
    Cytokeratin?14?is a?member of the type?I?keratin family of?intermediate filament?proteins.?It?always?pairs?with?the?type?II
    keratin?K5 and form the?primary?keratin?pair of the?keratinocytes of?stratified?squamous?epithelia,?including the?epidermis?as?well as?mucosal?non-keratinizing stratified squamous epithelia.
    Cytokeratin?14?is strongly expressed?in the?undifferentiated?basal cell?layer containing?the?stem?cells?and?are?down-regulated??in the differentiating suprabasal cell?layers. Otherwise,?in?the?widely?well?stratified?follicular?outer?rootsheath,?cytokeratin?14?is?uniformly expressed throughout all?layers. The expression?spectrum?of cytokeratin?14?in?tumors?corresponds?well?to?the
    patterns?in?normal epithelia. Thus,?most squamous cell carcinomas?as?well?as?malignant?mesotheliomas?strongly?express this?keratin whereas?little, focal, or?no expression?is found?in?adenocarcinomas.
    Cytokeratin?14?may?be a?useful?marker?in the differential diagnosis of?squamous?cell?carcinoma?from?other?epithelial?tumors.?Recent studies also?indicate that CK14 expression?in?breast?cancer?corresponded?with?poor?clinical?outcome?and?that?CK14
    may?have diagnostic value?in the sub-classification?of?NSCLC.
    Subcellular?location:
    Cytoplasm
    Recommended?method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Synthetic?peptide corresponding to cytokeratin?14
    residues?within?aa372-472 of?cytokeratin?14?was?used as an?immunogen.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage conditions:
    -25°C?to?-18°C
    Storage instructions:
    Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
    Recommended?Dilutions:
    IHC-P:?????1:100-1:200
    Background?References:
    1. ?Reis-Filho?JS, et.al. Virchows?Arch.?2003?Aug;443(2):122-32.
    2. ?Moll?R, et.al.?Histochem?Cell?Biol.?2008 Jun;129(6):705-?33.
    Immunohistochemistry?(Formalin/PFA-fixed
    paraffin-embedded
    sections analysis?of
    esophagus tissue
    labelling?cytokeratin?14?with?BP6052.?Heat
    mediated?antigen
    retrieval?was?performed?using Tris/EDTA?buffer????pH?9.0

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