• CD79a兔單克隆抗體

    CD79a兔單克隆抗體

    • 價(jià)格￥600
    • 規格100ul
    • 貨號HKZ150158
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150158CD79a兔單克隆抗體100ul支600
    CD79a
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    ?
    Catalog# ?BX50035?Clone# ?BP6040
    ?
    Predicted?Molecular Wt:
    25kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID: ??P11912
    Background:
    Cluster of differentiation CD79a also?known?as?B-cell?antigen?receptor?complex-associated?protein?alpha?chain?is?a?protein that
    in?humans?is?encoded?by?the?CD79A?gene. The?CD79a?protein?together?with?the?related?CD79b?protein,?forms?a?dimer ??associated with?membrane-bound?immunoglobulin?in?B-cells, thus forming the?B-cell antigen?receptor?(BCR),and?plays?multiple and diverse?roles?in?B cell development?and?function.
    ?
    CD79a?protein?is expressed?in virtually all?mature and?immature?B?cells and?the?majority?of?B-cell?neoplasms,?including
    precursor?B–acute?lymphocytic?leukemia?(pre-B–ALL),?L and?H?lymphocyte?predominance?Hodgkin’s?lymphoma, and?many?plasma cell?tumors.
    ?
    Therefore, antibodies to CD79a are?useful?in the?differential?diagnosis?of?B-cell?neoplasms from?T-cell?neoplasms?or?myeloid????neoplasms, or?L and?H?lymphocyte?predominance?Hodgkin’s?lymphoma from classic?Hodgkin’s?lymphoma.?In?addition,?CD79a?is a?useful?marker?in the diagnosis of?precursor?B–acute?lymphoblastic?leukemia?(pre-B–ALL)?because?many of these?tumors????are?negative?for?other?B-cell?markers, such?as?CD20?and?CD45RA.
    Subcellular?location:
    Membrane
    Recommended?method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Synthetic?peptide corresponding to CD79a?residues?????within?aa1-100 of?CD79a?was?used?as?an?immunogen.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage conditions:
    -25°C?to?-18°C
    Storage instructions:
    Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
    Recommended?Dilutions:
    IHC-P:?????1:100-1:200
    Background?References:
    1.?Seda?V, et.al,?Eur?J?Haematol.?2015?Mar;94(3):193-205.
    2.?Chu?PG, et.al,Appl?Immunohistochem?Mol?Morphol.
    2001 Jun;9(2):97-106.
    Immunohistochemistry?(Formalin/PFA-fixedparaffin-embedded
    sections analysis?of tonsil?tissue?labelling?CD79a
    with?BP6040.?Heat mediated?antigen
    retrieval?was?performed?using Tris/EDTA?buffer????pH?9.0

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