• p63兔單克隆抗體

    p63兔單克隆抗體

    • 價(jià)格￥1000
    • 規格100ul
    • 貨號HKZ150156
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150156p63兔單克隆抗體100ul支1000
    p63
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    ?
    Catalog# ?BX50033?Clone# ?BP6038
    ?
    Predicted?Molecular Wt:
    77kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID:??Q9H3D4
    Background:
    p63?is a transcription factor?related to the tumor suppressor?gene?p53?and?play?acritical?role?in the?development?of?stratified??epithelia?by?maintaining?basal cell?regenerative capacity?and?perhaps?by?playing a?role?in?mediating ectodermal-mesenchymal?interactions.
    In?normal tissues,?p63 expression?is?presented?in the?basal cells of?stratified?epithelia?such?as?skin,?ectocervix,?esophagus,
    urothelium, and?bronchi.?p63?is also found?in?basal cells of?glandular?tissue?such?as?prostate?and?breast?and?in?lymphoid?tissue.?In tumor tissues, the?p63 gene?is amplified and the?protein?is?overexpressed?in?primary?lung?and?head?and?necksquamous?cell
    carcinomas. Squamous cell carcinomas of the?larynx,?esophagus,?skin,?and?cervix?also?express?p63.?p63?expression?has?also?been?documented?in?basal cell carcinomas of skin.?However,?some studies?also?show?that?p63?expressed?in?a?subset?of
    adenocarcinomas and?large cell carcinomas?of?lung.
    In?diagnostic?pathology?practice,?p63?has?been studied as a?marker of?basal?cells to?help?in?the?diagnosis?of?ductal?carcinoma?in?situ of the?breast versus?invasive carcinoma?in fine-needle aspirates.?Similarly,?p63?has?been tested?as?a?marker?to?identify
    basal cells?in the diagnostic work-up for?prostatic?cancer.?Recently,?some studies?have?suggested?that?p63?in?combination?with?other?markers?may?be?used to?help?in?differentiating squamous cell carcinomas from?other tumor?types?in?cases?difficult?to
    diagnose?histologically.
    Subcellular?location:
    Nucleus
    Recommended?method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)
    for?30?minutes.
    Immunogen:
    Synthetic?peptide corresponding to?p63?residues within?aa580-680 of?p63 was?used?as?an?immunogen.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage conditions:
    -25°C?to?-18°C
    Storage instructions:
    Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
    Recommended?Dilutions:
    IHC-P:?????1:100-1:200
    Background?References:
    1.?Au?NH, et.al,Appl?Immunohistochem?Mol?Morphol.
    2004 Sep;12(3):240-7.
    2. ?Lewis?JS, et.al,?Mod?Pathol.?2005?Nov;18(11):1471-81.
    Immunohistochemistry?(Formalin/PFA-fixed
    paraffin-embedded
    sections?analysis of SCC?of?lung tissue?labelling???p63 with?BP6038.?Heat ?mediated?antigen
    retrieval?was?performed?using Tris/EDTA?buffer????pH?9.0
    ?

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