• p40兔單克隆抗體

    p40兔單克隆抗體

    • 價(jià)格¥1000
    • 規格100ul
    • 貨號HKZ150151
    • 單位
    • 品牌HaoKebio

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    HaoKebioHKZ150151p40兔單克隆抗體100ul1000
    p40
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    Catalog# ?BX50028?Clone# ?BP6033
    Predicted?Molecular Wt:
    66kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID:??Q9H3D4-2
    Background:
    p40 antibody?(antibody?recognizing?ΔNp63 only)?is?an?isoform?of?p63,?is?thought?to?function?as?a?stem?cell?factor,?responsible for?maintaining cells?in an?uncommitted state with?regenerative?potential—a?role that?may?be?recapitulated?in tumors
    derived from these?cells.
    p40?is?normally expressed?in the?basal or?progenitor cell?layer?of stratified?epithelia?(eg.?squamous,?urothelial,?bronchial),
    basal cells of some glandular epithelia?(eg.?prostate),?as well?as?myoepithelial?cells?of?breast?and?salivary?glands,?trophoblasts?and thymicepithelial cells.?In tumor tissues,?p40 expression?is specific for?squamous?cell?carcinoma.
    ?
    p40?is equivalent to?p63?insensitivity for?lungsquamous cell carcinoma,?but?it?is?markedly?superior to?p63?in?specificity,?which eliminates a?potential?pitfall of?misinterpreting a?p63-positive?adenocarcinoma?or?unsuspected?lymphoma?as
    squamous cell carcinoma.?p40 appears to?be a?more?reliable?marker?for?squamous?cell?carcinoma.
    ?
    Subcellular?location:
    Nucleus
    Recommended?method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Synthetic?peptide corresponding to?p40?residues?????within?aa1-100 of?p40 was?used?as?an?immunogen.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage conditions:
    -25°C?to?-18°C
    Storage instructions:
    Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
    Recommended?Dilutions:
    IHC-P:?????1:100-1:200
    Background?References:
    1. ?Nonaka?D?et.al, Am?J?Surg?Pathol.?2012 Jun;36(6):895-?9.
    2. ?Bishop?JA?et.al,?Mod?Pathol.?2012?Mar;25(3):405-15.
    Immunohistochemistry
    (Formalin/PFA-fixed
    paraffin-embedded
    sections analysis?of
    prostate tissue?labelling
    p40 with?BP6033.?Heat
    mediated?antigen?retrieval?was?performed?using
    Tris/EDTA?buffer?pH?9.0

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