• CYC1兔多克隆抗體

    CYC1兔多克隆抗體

    • 價(jià)格￥1200
    • 規格50ul
    • 貨號HK210116S
    • 單位支
    • 品牌HaoKebio

    產(chǎn)品介紹
    產(chǎn)品參數
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    品牌商品編碼商品名稱(chēng)規格單位單價(jià)
    HaoKebioHK210116SCYC1兔多克隆抗體50ul支1200

    Applications

    Tested Applications:
    IHC, WB,ELISA

    Cited Applications:
    IHC, WB
    Species Specificity:
    human, mouse

    Cited Species:
    human, monkey, mouse, pig

    Positive WB detected in:
    human brain tissue

    Positive IHC detected in:
    human liver cancer tissue, human breast cancer tissue
    Note: suggested antigen retrieval with?TE buffer pH 9.0;?(*) Alternatively, antigen retrieval may be performed with?citrate buffer pH 6.0

    Recommended dilution:
    WB : 1:500-1:2000
    IHC : 1:50-1:500
    Product Information

    Source:
    Rabbit

    Purification method:
    Antigen affinity purification

    Isotype:
    IgG

    Storage:
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
    Store at -20°C. Stable for one year after shipment.?Aliquoting is unnecessary for -20oC storage.
    Immunogen Information

    Full name:
    cytochrome c-1

    Calculated molecular weight:
    35 kDa

    Observed molecular weight:
    35 kDa



    Gene symbol
    CYC1

    Synonyms
    Complex III subunit 4, Complex III subunit IV, CYC1, cytochrome c 1, UQCR4
    Background
    CYC1, also named as Cytochrome c-1, belongs to the cytochrome c family. Cytochrome c1 is one respiratory subunit of the 11 subunits of the cytochrome bc1 complex of the mitochondrial electron-transfer chain. It mediates the transfer of an electron from Rieske iron-sulfur protein to cytochrome c(PMID:3036122 ). CYC1 mediates apoptosis. In this pathway, a variety of apoptotic stimuli cause CYC1 release from mitochondria, which in turn induces a series of biochemical reactions that result incaspase activation and subsequent cell death.(PMID:15189137) While CYC1 release and DNA fragmentation are unaffected by the noncleavablep75 mutant, mitochondrial morphology of dying cells is maintained, and loss of plasma membrane integrity is delayed(PMID:15186778). The protein migrated as a 35 kd band in SDS page.

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