• Islet-1兔單克隆抗體

    Islet-1兔單克隆抗體

    • 價(jià)格￥1800
    • 規格100ul
    • 貨號HKZ150426
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150426Islet-1兔單克隆抗體100ul支1800
    Islet-1
    Recombinant?Rabbit?Monoclonal Antibody Product?Datasheet
    Catalog#?BX50303 Clone#?BP6280
    Predicted?Molecular Wt:
    39kDa
    Purity:??ProA affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form:??Liquid
    Applications:
    IHC-P
    Swissprot?ID:??P61371
    Background:
    Islet-1,a?human?insulin gene enhancer-binding?protein,?is a transcription factor?involved?in?the?differentiation?of the
    neuroendocrine?pancreatic cells.?Islet-1?plays an?important?role?in the embryogenesis and?differentiation?of?the?insulin
    producing?pancreatic?beta cells within the?islets of?Langerhans.?Neuroendocrine tumors?can?arise from?a?variety?of?primary?????sites,?most commonly?in the?bronchopulmonary system, gastrointestinal?(GI) tract,?and?pancreas.Neuroendocrine tumors?of??the GI tract and?pancreas tend to?be?slow growing?and?indolent,?and?may?metastasize?to?the?liver?before?it?is?detected.Islet-1
    exhibits strong?nuclear?staining?in the?islets of?normal?pancreas and tumor?cells?of the?pancreatic?neuroendocrine?tumor.?Islet-1?has?been?shown to?be?a?reliable?marker for the detection of?primary?and?metastatic?pancreatic?neuroendocrine
    neoplasms.
    Subcellular?location:
    Nucleus
    Recommended?Method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Synthetic?peptide. This?information?is?proprietary to?Biolynx.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage Conditions:
    -25°C?to?-18°C
    Shipment?Instructions:
    Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?–?18°C. Avoid?freeze?/ thaw?cycles.
    Recommended?Dilution:
    IHC-P:?????1:100-1:200
    Background?References:
    1.?Schmitt?AM, ,?et?al. Am?J?Surg?Pathol.?2008?Mar;32(3):420-5.
    2.?Ediger?BN,?et?al. ?Diabetes.?2014?Dec;63(12):4206-17.
    Immunohistochemistry?(Formalin/PFA-fixed?paraffin-embedded?sections) analysis of ?of?human?pancreas tissue sections?labeling?Islet-1 with?BP6280.

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