• Stathm in兔單克隆抗體

    Stathm in兔單克隆抗體

    • 價(jià)格￥1000
    • 規格100ul
    • 貨號HKZ150387
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150387Stathm in兔單克隆抗體100ul支1000
    Stathmin
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    Catalog# ?BX50264?Clone# ?BP6241
    Predicted?Molecular Wt:
    17kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID: ??P16949
    Background:
    Stathmin /oncoprotein?18, also?known as STMN1,?performs an?important function?in?regulating?rapid?microtubule?remodeling?of the cytoskeleton?in?response to the cell’s?needs.?Regulation of stathmin?is?cell?cycle?dependent?and?controlled?by?the?cell’s???protein?kinases?in?response to specific cell signals. Stathmin?can?cause?uncontrolled?cell?proliferation?when?mutated?and?not????functioning?properly.
    Overexpression of Stathmin?has?been associated with tumor?progression?in?endometrial?carcinomas,?ovarian?cancer?and?oral?squamous-cell carcinoma. Stathmin?has?been found to?be?positive?in?29% of cervical?intraepithelial?neoplasia?(CINs)?with
    differential?expression?based?on?the?grade?of?the?lesion?as?9%?being?CIN1,?45%?CIN2,?and?93%?CIN3;?whereas,?p16?staining?of ??the?same?cases?was?positive?in?80% of?CINs?with?71% CIN1,?100%?CIN2,?and?94%?CIN3.?Stathmin?shows?similar?sensitivity?for ????CIN3 to?anti-p16?(93% vs?94%) although?it?drops?off?for?CIN2?(73% vs?96%). The?specificity?of?stathmin?antibody?for?both?CIN2-?3?(94%) and?CIN3?(89%)?is?higher?than?that?of?anti-p16?(44% and?39%,?respectively). Therefore,?Stathmin?antibody?has?major ?potential as a diagnostic?marker?in CIN?classification?over?anti-p16?and?it?is valuable?to?distinguish?CIN3?from?the?majority?of?????low-grade?precursors and?negative/reactive cervical?biopsies.
    Subcellular?location:
    Membrane/cytoplasm
    Recommended?Method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Synthetic?peptide. This?information?is?proprietary to?Biolynx.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage Conditions:
    -25°C?to?-18°C
    Shipment?Instructions:
    Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
    Recommended?Dilution:
    IHC-P:?????1:100-1:200
    Background?References:
    1.??Atweh, G., et?al. J?Cellular?Biochemistry?2004;?93?(2):?242–250.
    2. ??Howitt?B, et?al.: Am?J?Surg?Pathol?2013,?37:89-97
    Immunohistochemistry?(Formalin/PFA-fixed?paraffin-
    embedded?sections)?analysis of tonsil?labelling Stathmin?with?BP6241.

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