• Neurofilament鼠單克隆抗體

    Neurofilament鼠單克隆抗體

    • 價(jià)格￥600
    • 規格100ul
    • 貨號HKZ150372
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150372Neurofilament鼠單克隆抗體100ul支600
    Neurofilament
    Mouse?Monoclonal Antibody?Product?Datasheet
    Catalog# ?BX50249???Clone# ?BPM6226
    Predicted?Molecular Wt:
    102kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID: ??P07197
    Background:
    Neurofilaments are the?major?intermediate filaments found?in?neurons and consist?of?light?(NFL),?medium?(NFM),and?heavy?(NFH) subunits. Similar?in structure to other?intermediate filament?proteins,?neurofilaments?have?a?globular?amino-terminal??head, a central α-helical?rod domain,?and?a?carboxy-terminal?tail.?A?heterotetrameric?unit?(NFL-NFM?and?NFL-NFH)?forms?a????protofilament, with eight?protofilaments comprising the typical?10?nm?intermediate filament.
    Research studies?have shown?neurofilament accumulations?in?many?human?neurological disorders?including?Parkinson’s
    disease?(in?Lewy?bodies along with α-synuclein), Alzheimer’s disease,?Charcot-Marie-Tooth?disease,?and Amyotrophic?Lateral?Sclerosis?(ALS).
    Neurofilament antibody?mainly stains?neurons?in tissue sections of?brain?and?other?tissues.?Neurofilament?has?been?shown?to?react with?neuroblastomas, gangliomas,?pheochromocytomas,?Merkel cell tumors and carcinoid?tumors.
    Subcellular?location:
    Cytoplasm
    Recommended?Method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:Recombinant full-length?protein correspongding to?human?Neurofilament.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage Conditions:
    -25°C?to?-18°C
    Shipment?Instructions:
    Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
    Recommended?Dilution:
    IHC-P:?????1:100-1:200
    Background?References:
    1. ?Franquemont?DW, et?al. Am?J?Clin?Pathol?1994 Aug;102(2):163-70.
    2. ?Diepholder?HM, et?al.?Cancer?1991?Nov?15;68(10):2192-201.
    Immunohistochemistry?(Formalin/PFA-fixed?paraffin-?embedded?sections)?analysis?of?brain?labelling
    Neurofilament?with?BPM6226.

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