• Progesterone Receptor兔單克隆抗體

    Progesterone Receptor兔單克隆抗體

    • 價(jià)格￥1000
    • 規格100ul
    • 貨號HKZ150255
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150255Progesterone Receptor兔單克隆抗體100ul支1000
    Progesterone?Receptor
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    Catalog# ?BX50132?Clone# ?BP6136
    Predicted?Molecular Wt:
    99kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID: ??P06401
    Background:
    Progesterone?is one of the central?regulators of female?reproduction.?In?breast?development,?progesterone?is?involved?in the???formation of?lobular-alveolar structures and also?affects?differentiation?in?the?breast?by?modulation?of?milk?protein?synthesis.??The cellular effects of?progesterone are?mediated through?progesterone?receptors?(PR).?PR,a?protein?with?946?amino?acids,?is?a?ligand-activated transcription factor?member of the steroid?receptor superfamily?of?nuclear?receptors.?PR?is?predominantly??expressed?in female sex steroid?responsive tissues such?as the?mammary?gland,?uterus?and?ovary?but?is?also found?in?other
    tissues such as endocrine cells?of the?Langerhans’?islets.
    The estrogen?receptor?(ER) and?PR status?has?been?used for?over?20 years?as?a?predictor?of?breast?carcinoma?responsiveness to?endocrine therapy and as a?prognostic?indicator for?early?recurrence.
    Subcellular?location:
    Nucleus
    Recommended?method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Recombinant?protein corresponding to?residues within?aa400-600 of??progesterone?receptor?was?used?as?an
    immunogen.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage conditions:
    -25°C?to?-18°C
    Storage instructions:
    Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
    Recommended?Dilutions:
    IHC-P:?????1:100-1:200
    Background?References:
    1. ?Bardou?V-J, ArpinoG,?Elledge?RM, et?al. J?Clin?Oncol 2003;21:1973-1979.
    2.??Elledge?RM, GreenS,?Pugh?R etal.??Int J?Cancer?2000;89:111-117.
    Immunohistochemistry
    (Formalin/PFA-fixed
    paraffin-embedded
    sections)?analysis of
    breast?carcinoma tissue?labelling?Progesterone
    Receptor?with?BP6136.
    Heat?mediated?antigen
    retrieval was?performed????using Tris/EDTA?buffer?pH?9.0

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