• RRM1兔單克隆抗體

    RRM1兔單克隆抗體

    • 價(jià)格￥2200
    • 規格100ul
    • 貨號HKZ150241
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150241RRM1兔單克隆抗體100ul支2200
    RRM1
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    Catalog# ?BX50118?Clone# ?BP6122
    Predicted?Molecular Wt:
    90kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID: ??P23921
    Background:
    Ribonucleotide?reductase?M1?polypeptide?(RRM1)?is one of two?non-identical subunits for?ribonucleoside-diphosphate
    reductase, an enzyme which catalyzes the?biosynthesis?of?deoxyribonucleotides from the?corresponding?ribonucleotides.?It
    provides the?precursors?necessary for?DNA synthesis.?RRM1?is?present throughout the cell?division?cycle?but?downregulated?in??quiescent cells.?RRM1?is?involved?in carcinogenesis, tumor?progression, and the?response?of?non-small-cell?lung?cancer?(NSCLC)?to chemotherapy.
    Subcellular?location:
    Cytoplasmic
    Recommended?method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Synthetic?peptide corresponding to?residues within?aa700-800 of??Human?RRM1 was?used?as?an
    immunogen.
    Storage?Buffer:
    0.05%. ??????????????????????????????????????????????????????????????????????????????????????
    Storage conditions:
    -25°C?to?-18°C
    Storage instructions:
    Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
    Recommended?Dilutions:
    IHC-P:?????1:100-1:200
    Background?References:
    1.?Wang,Q, et?al.?PLoS?ONE.?2013 Jul;8(7):1-12.
    2. ??Nordlund?P, et?al. Annu?Rev?Biochem.?2006; 75:681–706.
    Immunohistochemistry?(Formalin/PFA-fixed
    paraffin-embedded
    sections)?analysis of
    breast?carcinoma tissue?labelling?RRM1 with
    BP6122.?Heat?mediated antigen?retrieval was
    performed?using
    Tris/EDTA?buffer?pH?9.0

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