• p120兔單克隆抗體

    p120兔單克隆抗體

    • 價(jià)格￥1000
    • 規格100ul
    • 貨號HKZ150193
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150193p120兔單克隆抗體100ul支1000
    p120
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    Catalog# ?BX50070?Clone# ?BP6075
    Predicted?Molecular Wt:
    108kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID:??O60716
    Background:
    Alpha-catenin and?beta-catenin?bind to the?intracellular domain of?E-cadherin?while?p120?catenin?binds?E-cadherin?at?a juxta-?membrane site. The complex stabilizes tight junctions.?In the cell,?p120?catenin?localized?to?the?E-cadherin/catenins?cell
    adhesion complex, directly associates with?cytoplasmic?C-terminus?of?E-cadherin?and?may?similarly?interact with?other?cadherins.
    p120?is a?proliferation-associated?nucleolar?protein found?in?most?human?malignant tumors,?but?not?in?resting?normal cells.?In?colorectal cancer the altered?localization of?p120 catenin?corresponds?with?loss?of?cytoplasmic?localization?of?E-cadherin.
    Studies?have shown accurate categorization of?ductalvs.?lobular?neoplasia?in the?breast?was?achieved?with?p120?staining.?p120 expression further clarifies the separation?of?low-grade?ductal?carcinoma?in?situ from?lobular?neoplasia.?Studies?also?have shown that altered expression?of?p120 catenin?antibody?predicts?poor?outcome?in?invasive?breast?cancer.
    Subcellular?location:
    Cytoplasm and?membrane
    Recommended?method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Synthetic?peptide corresponding to?p120?residues?within?aa900-1000 of??p120 was?used?as?an
    immunogen.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage conditions:
    -25°C?to?-18°C
    Storage instructions:
    Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
    Recommended?Dilutions:
    IHC-P:?????1:100-1:200
    Background?References:
    1.?Talvinen?K, et?al. Altered?expression?of?p120 catenin predicts?poor outcome?in?invasive?breast cancer. J?????Cancer?Res?Clin?Oncol.?2010 Sep;?136(9):1377-87.
    ?2.?Chivukula?M, et al.?Pleomorphic?lobular carcinoma?in
    situ?(PLCIS) on?breast core?needle?biopsies: clinical
    significance?and?immunoprofile. Am?J?Surg?Pathol.?2008?Nov; 32(11):1721-6.
    Immunohistochemistry
    (Formalin/PFA-fixed
    paraffin-embedded
    sections?analysis of?colon?tissue?labelling?p120 with BP6075.?Heat?mediated ???antigen?retrieval was
    performed?using
    Tris/EDTA?buffer?pH?9.0

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