CD3兔單克隆抗體

價(jià)格￥600
規格100ul
貨號HKZ150145
單位支
品牌HaoKebio

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產(chǎn)品參數

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品牌	商品編碼	商品名稱(chēng)	規格	單位	單價(jià)
HaoKebio	HKZ150145	CD3兔單克隆抗體	100ul	支	600

CD3
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
?
Catalog# ?BX50022?Clone# ?BP6027
?
Predicted?Molecular Wt:
23kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P07766
?

Background:
The CD3?protein?is a T-cell?marker,a complex?of four?structurally?distinct?membrane?glycoprotein?isoforms,?comprising
extracellular, transmembrane and?intracellular domains. The CD3 complex?is?responsible?for?mediating?signal?transduction?to?the?internal environment?upon antigenic?recognition?by TCR, causing T-cell?proliferation?and?release of?cytokines.
?
CD3?is?found?only?in?T-cells.?In?malignant?lymphomas, CD3?is?a?pan-T-cell?lineage-restricted?antigen, detected?in?80-97%?of?the T-cell?lymphomas.?Mature T-cell?lymphomas?including cases of?mycosis fungoides,?peripheral T-cell?lymphoma and?anaplastic??large cell?lymphoma?may aberrantly?lose CD3.
?
CD3?is an?important?marker?in the classification of?malignant?lymphomas and?lymphoid?leukaemias.
?Subcellular?location:
Membrane
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to CD3E?residues?????within?aa1-100 of?CD3E?was?used?as?an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1.?Walts?AE,et.al,?Diagn?Cytopathol.?2012 Jul;40(7):565-9.
?
2. ?Hudacko?R, et.al,?Mod?Pathol.?2013 Sep;26(9):1241-5.
Immunohistochemistry?(Formalin/PFA-fixed
paraffin-embedded
sections analysis?of tonsil?tissue?labelling?CD3 with??BP6027.?Heat?mediated ???antigen?retrieval was
performed?using Tris/EDTA?buffer?pH?9.0

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