• SOX10兔單克隆抗體

    SOX10兔單克隆抗體

    • 價(jià)格￥600
    • 規格100ul
    • 貨號HKZ150142
    • 單位支
    • 品牌HaoKebio

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    HaoKebioHKZ150142SOX10兔單克隆抗體100ul支600
    SOX10
    Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
    ?
    Catalog# ?BX50019?Clone# ?BP6024
    ?
    Predicted?Molecular Wt:
    50kDa
    Purity: ??ProA?affinity?purified?IgG
    Species Cross-reactivity:
    Human
    Form: ??Liquid
    Applications:
    IHC-P
    Swissprot?ID: ??P56693
    ?

    Background:
    SOX10?is a?member of the SRY-related?HMG-box?(SOX) family of transcription?factors?involved?in?the?regulation?of?embryonic?development and?in the determination of cell?fate.?During?development,?SOX10?first?appears?in?the?forming?neural?crest?and??continues to?be expressed?in Schwann cells.?It?is?important for?differentiation,?maturation?and?maintenance?of Schwann?cells?and?melanocytes.
    ?
    In?normal tissues, SOX10?is expressed?in Schwann cells?and?glial?cells?in?the?nervous?system.?It?is?also?detected?in?melanocytes???and epithelial cells of salivary gland?and?mammary?gland.?In?tumor?tissues,?SOX10?labels?melanoma?and?tumors?of?neural?crest?origin.
    ?
    SOX10?is?more specific than S100?protein?in the detection?of?melanocytic?and?schwannian?neoplasms,?and?has?in?some?studies?shown?more sensitive.
    ?Subcellular?location:
    Nucleus
    Recommended?method:
    Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
    Immunogen:
    Synthetic?peptide corresponding to SOX10?residues
    within?aa366‐466 of?SOX10?was?used?as?an immunogen.
    Storage?Buffer:
    PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
    Storage conditions:
    -25°C?to?-18°C
    Storage instructions:
    Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
    Recommended?Dilutions:
    IHC-P:?????1:100-1:200
    Background?References:
    1. ?Ken?Inoue,. et?al.?Human?Molecular?Genetics,?2007,?Vol.?16,?No.?24.
    2. ?Nonaka?D1,. et?al.?Am?J?Surg?Pathol.?2008?Sep;32(9):1291-8.
    Immunohistochemistry?(Formalin/PFA-fixed
    paraffin-embedded sections)?analysis of?human
    melanoma tissue?labelling??SOX10 ?with?BP6024.?Heat ?mediated?antigen?retrieval?was?performed?using
    Tris/EDTA?buffer?pH?9.0

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