• APOL1兔多克隆抗體

    APOL1兔多克隆抗體

    • 價(jià)格￥1960/￥2800
    • 規格100ul/200ul
    • 貨號HK210013M/HK210013L
    • 單位支
    • 品牌HaoKebio

    產(chǎn)品介紹
    產(chǎn)品參數
    資料下載
    品牌商品編碼商品名稱(chēng)規格單位單價(jià)
    HaoKebioHK210013MAPOL1兔多克隆抗體100ul支1960
    HaoKebioHK210013LAPOL1兔多克隆抗體200ul支2800

    Applications

    Tested Applications:
    FC, IF, IHC, IP, WB, ELISA

    Cited Applications:
    IF, IHC, IP, WB
    Species Specificity:
    human

    Cited Species:
    human, mouse, Trypanosoma brucei

    Positive WB detected in:
    human blood tissue, A549 cells, SKOV-3 cells, HeLa cells, MCF-7 cells, HepG2 cells, A2780 cells, SW 1990 cells, human plasma tissue

    Positive IP detected in:
    HepG2 cells, human plasma tissue

    Positive IHC detected in:
    human kidney tissue, human spleen tissue, human liver tissue, human pancreas tissue, human testis tissue
    Note: suggested antigen retrieval with?TE buffer pH 9.0;?(*) Alternatively, antigen retrieval may be performed with?citrate buffer pH 6.0

    Positive IF detected in:
    HepG2 cells

    Positive FC detected in:
    HepG2 cells

    Recommended dilution:
    WB : 1:500-1:1000
    IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
    IHC : 1:20-1:200
    IF : 1:10-1:100
    Product Information

    Source:
    Rabbit

    Purification method:
    Antigen affinity purification

    Isotype:
    IgG

    Storage:
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
    Store at -20°C. Stable for one year after shipment.?Aliquoting is unnecessary for -20oC storage.
    Immunogen Information

    Full name:
    apolipoprotein L, 1

    Calculated molecular weight:
    44 kDa

    Observed molecular weight:
    39 kDa


    Gene symbol
    APOL1

    Synonyms
    APO L, APOL, APOL I, APOL1, Apolipoprotein L, Apolipoprotein L I, apolipoprotein L, 1, Apolipoprotein L1
    Background
    Human apolipo-protein L1 (APOL1) is a minor component of plasma high density lipoprotein (HDL) particles, acting as an interacting protein of apolipoprotein A1 (ApoA1). The human ApoL protein family was thought to be predominantly involved in lipid transport and metabolism. APOL1 is also involved in host innate immunity against Trypanosoma parasites. Once activated, APOL1 can lyse the parasite and protect human from infection. Genetic variants in APOL1 gene, which are found in African ancestry with high frequency, associate with chronic kidney disease, like focal segmental glomerulosclerosis (FSGS), HIV-associated nephropathy (HIVAN), and hypertensive nephropathy. APOL1 share structural and functional similarities with proteins of the Bcl-2 family and may has roles in apoptosis and autophagy. It is notable that APOL1 exists only in human and a few other primate species, and mouse does not express an APOL1 orthologue. This antibody recognizes the endogenous APOL1 of 39-45 kDa in blood lysate.

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