• c-Met (Cytoplasmic)兔多克隆抗體

    c-Met (Cytoplasmic)兔多克隆抗體

    • 價(jià)格￥2800
    • 規格200ul
    • 貨號HK210105L
    • 單位支
    • 品牌HaoKebio

    產(chǎn)品介紹
    產(chǎn)品參數
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    品牌商品編碼商品名稱(chēng)規格單位單價(jià)
    HaoKebioHK210105Lc-Met (Cytoplasmic)兔多克隆抗體200ul支2800

    Applications

    Tested Applications:
    IHC, IP, WB,ELISA
    Cited Applications:
    IF, IHC, IP, WB
    Species Specificity:
    human, canine, mouse, rat

    Cited Species:
    human, mouse, rat

    Positive WB detected in:
    mouse liver tissue, MDCK cells, HepG2 cells, A431 cells, rat liver tissue

    Positive IP detected in:
    HeLa cells

    Positive IHC detected in:
    human breast cancer tissue, human colon tissue, human liver cancer tissue
    Note: suggested antigen retrieval with?TE buffer pH 9.0;?(*) Alternatively, antigen retrieval may be performed with?citrate buffer pH 6.0

    Recommended dilution:
    WB : 1:200-1:1000
    IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
    IHC : 1:20-1:200
    Product Information

    Source:
    Rabbit

    Purification method:
    Antigen affinity purification

    Isotype:
    IgG

    Storage:
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
    Store at -20°C. Stable for one year after shipment.?Aliquoting is unnecessary for -20oC storage.
    Immunogen Information

    Full name:
    met proto-oncogene (hepatocyte growth factor receptor)

    Calculated molecular weight:
    1390 aa, 155 kDa

    Observed molecular weight:
    145 kDa


    Gene symbol
    MET

    Synonyms
    AUTS9, c-Met, HGF receptor, HGF/SF receptor, HGFR, MET, Proto oncogene c Met, RCCP2, Scatter factor receptor, SF receptor, Tyrosine protein kinase Met
    Background
    c-Met (also named as MET or HGFR) is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to HGF ligand. c-Met regulates many physiological processes including proliferation, scattering, morphogenesis and survival. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Overexpression and/or mutation of c-Met has been reported in various human malignancies, including lung cancer, breast cancer, head and neck cancer, gastric cancer, colorectal cancer, bladder cancer, uterine cervix carcinoma, and esophageal carcinoma, c-Met could serve as an important therapeutic target (PMID: 26036285). The c-met receptor is a 190-kD glycoprotein consisting of a 145-kD membrane-spanning beta chain and a 50-kD alpha chain (PMID: 7806559). In Western blot, this antibody produces bands of unknown identity at 55 and 100 kDa.

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