• Cyclin B2兔多克隆抗體

    Cyclin B2兔多克隆抗體

    • 價(jià)格￥1200
    • 規格50ul
    • 貨號HK210119S
    • 單位支
    • 品牌HaoKebio

    產(chǎn)品介紹
    產(chǎn)品參數
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    品牌商品編碼商品名稱(chēng)規格單位單價(jià)
    HaoKebioHK210119SCyclin B2兔多克隆抗體50ul支1200

    Applications

    Tested Applications:
    IHC, IP, WB,ELISA

    Cited Applications:
    IHC, WB
    Species Specificity:
    human, mouse, rat

    Cited Species:
    human

    Positive WB detected in:
    HeLa cells, DU 145 cells, rat testis tissue, A431 cells, K-562 cells

    Positive IP detected in:
    A431 cells

    Positive IHC detected in:
    human cervical cancer tissue, human testis tissue, human colon cancer tissue
    Note: suggested antigen retrieval with?TE buffer pH 9.0;?(*) Alternatively, antigen retrieval may be performed with?citrate buffer pH 6.0

    Recommended dilution:
    WB : 1:500-1:2000
    IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
    IHC : 1:20-1:200
    Product Information

    Source:
    Rabbit

    Purification method:
    Antigen affinity purification

    Isotype:
    IgG

    Storage:
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
    Store at -20°C. Stable for one year after shipment.?Aliquoting is unnecessary for -20oC storage.
    Immunogen Information

    Full name:
    cyclin B2

    Calculated molecular weight:
    398 aa, 45 kDa

    Observed molecular weight:
    51 kDa

    Gene symbol
    CCNB2

    Synonyms
    CCNB2, cyclin B2, G2/mitotic specific cyclin B2, HsT17299
    Background
    Cyclin B2 (CCNB2) is a member of cyclin family proteins, which regulate the activities of cyclin dependent kinases (CDKs) and different cyclins function spatially and temporally in specific phases of the cell cycle. Cyclin B2 serves a key role in progression of G2/M transition. Cyclin B2 has been found to be up-regulated in a variety of human cancers, such as adrenocortical carcinoma, breast carcinoma, colorectal adenocarcinoma, pituitary adenoma and gastric cancer. The aberrant expression of Cyclin B2 deregulates spindle checkpoints in the cell cycle and results in chromosomal instability (CIN), one of the signature phenotypes of most cancers. Moreover, serum circulating Cyclin B2 mRNA expression has been found increased in cancer patients and associated with cancer stage and metastasis status.

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