• GADD34兔多克隆抗體

    GADD34兔多克隆抗體

    • 價(jià)格￥1960/￥2800
    • 規格100ul/200ul
    • 貨號HK210150M/HK210150L
    • 單位支
    • 品牌HaoKebio

    產(chǎn)品介紹
    產(chǎn)品參數
    資料下載
    品牌商品編碼商品名稱(chēng)規格單位單價(jià)
    HaoKebioHK210150MGADD34兔多克隆抗體100ul支1960
    HaoKebioHK210150LGADD34兔多克隆抗體200ul支2800

    Applications

    Tested Applications:
    IF, IHC, WB, ELISA

    Cited Applications:
    IF, IHC, IP, WB

    Species Specificity:
    human, mouse

    Cited Species:
    hamster, human, monkey, mouse, pig, rat

    Positive WB detected in:
    K-562 cells, HepG2 cells, Tunicamycin treated HeLa cells, Jurkat cells, PC-3 cells

    Positive IHC detected in:
    human pancreas tissue, human colon cancer tissue
    Note: suggested antigen retrieval with?TE buffer pH 9.0;?(*) Alternatively, antigen retrieval may be performed with?citrate buffer pH 6.0

    Positive IF detected in:
    PC-3 cells

    Recommended dilution:
    WB : 1:300-1:1000
    IHC : 1:50-1:500
    IF : 1:20-1:200
    Product Information

    Source:
    Rabbit

    Purification method:
    Antigen affinity purification

    Isotype:
    IgG

    Storage:
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
    Store at -20°C. Stable for one year after shipment.?Aliquoting is unnecessary for -20oC storage.
    Immunogen Information

    Full name:
    protein phosphatase 1, regulatory (inhibitor) subunit 15A

    Calculated molecular weight:
    73 kDa

    Observed molecular weight:
    100 kDa


    Gene symbol
    PPP1R15A

    Synonyms
    GADD34, growth arrest and DNA damage-inducible protein 34, PPP1R15A
    Background
    GADD34, also named PPP1R15A, belongs to the PPP1R15 family. GADD34 can be triggered as a direct target of activating transcription factor4 (ATF4) under ER stress, it plays a pivotal role in the recovery of cells from shut-down of translation induced by ER stress. It recruits the serine/threonine-protein phosphatase (PP1) to dephosphorylate the translation initiation factor eIF2alpha, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. GADD34 down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 via PP1. It may also promote apoptosis by inducing TP53 phosphorylation on ‘Ser-15’. Starvation-induced expression of GADD34 reduced mTOR activity and induced autophagy in wild-type mice, but not in GADD34 KO mice. Molecular weight of GADD34 is 100 kDa confirmed in GADD34 KO mice, and Proteintech’s GADD34 antibody 10449-1-AP primarily recongize the 100 kDa band.

    暫無(wú)

    說(shuō)明文檔下載

    上一篇: 下一篇:

    推薦

    您好！請登錄

    點(diǎn)擊取消回復
      展開(kāi)更多
      點(diǎn)擊展開(kāi)我們的聯(lián)系方式
      丝袜美腿精品国产一区|吉泽明歩一区二区三区中文字幕|超碰97人人模人人爽人人|久久中文字幕永久第一页